Indeed, this has been suggested to occur in alveolar soft-part sarcoma, since TFE3, the transcription factor translocated and overexpressed in these tumors, is involved in the regulation of expression of transforming growth factor-beta (TGF-β), a well-known mediator of immune suppression, as well as the receptor tyrosine kinase MET, which can affect PD-L1 expression through activation of the PI3K pathway [63,64]. This evidence concerns the gene CD274 and sarcoma.