As an example, ipilimumab, which targets CTLA-4 on T cells, showed beneficial responses when combined with nivolumab, an anti-PD-1 antibody, compared to nivolumab mono treatment in various soft tissue sarcomas, including leiomyosarcomas, myxofibrosarcomas, undifferentiated soft tissue sarcomas, and angiosarcomas [100]. This evidence concerns the gene CTLA4 and soft tissue sarcoma.