TXN and aortic valve stenosis: Patients with AS had significantly higher levels (p = 0.0008) of TRX1 compared to controls (Figure 2a,b), but the ROC analysis showed that TRX1 cannot serve as a specific and sensitive biomarker for AS stenosis without grading the severity (poor level: AUC = 0.66, p = 0.0052) (Figure 2c).