TXN and aortic valve stenosis: Our findings (by the ROC analysis) suggest that TRX1 might serve as a specific and sensitive biomarker only in mild AS patients (good level: AUC = 0.82, p = 0.0001) (Figure 5), but it did not serve as a specific and sensitive biomarker in patients with moderate to severe AS (AUC = 0.54, p = 0.66; AUC = 0.65, p = 0.08).