The aim of this study was to evaluate the plasma levels of TRX1 and also MPO, chemerin and growth factors GDF-15, Ang-2, VEGF-A, FGF-2, FGF-21, MPP-1, -3, -9, and C-reactive protein (CRP) in acquired AS patients as well as to clarify the correlations of TXR1 and the plasma inflammatory biomarkers regarding AS severity. The gene discussed is GDF15; the disease is aortic valve stenosis.