MT-ND3 and neoplasm: Across the whole list, the most highly downregulated were the 2-oxoglutarate/malate carrier protein OGC (SCL25A11), MT-ND3 (a tumor suppressor that participates in the malate-aspartate shuttle and regenerates the NADH pool in the mitochondrial matrix to allow complex I function), the NADH dehydrogenase subunit 3 of complex I, the gamma-aminobutyric acid aminotransferase ABAT, and the ubiquinol-cytochrome C reductase subunit of complex III.