ANGPTL4 and type 2 diabetes mellitus: In addition, the upregulation of circulating ANGPTL4 in obese patients with T2D has been reported by a large population study, demonstrating a positive correlation between plasma ANGPTL4 concentrations and fasting plasma glucose [29], and by another investigation, showing that the plasma levels of ANGPTL4 are almost two-fold higher in patients with T2D than in nondiabetic controls [34].