The broad screening of A-, B- and D-lactam steroid alkylators for anticancer activity against several panels of human cancer cell lines (breast cancer, colon cancer, pancreatic cancer, small-cell-lung cancer cells) showed that these compounds produce their cytostatic and cytotoxic effects independently of the presence of different inactivating mutations of TP53 (data not shown). Here, TP53 is linked to familial pancreatic carcinoma.