This overactivation phenomenon, “emerging” both from PARP1 and PARP2 in all tested cell lines is also emphasized in our results in the wild-type cancer cells (without BRCAness), promoting the NAD depletion/energy cell “starvation” as an alternative procedure leading to cellular death, even for more enduring carcinomas, with a mechanism for these compounds similar to the one reported for lactam-steroidal alkylators [21]. This evidence concerns the gene PARP2 and cancer.