TP53 and malignant colon neoplasm: The broad screening of A-, B- and D-lactam steroid alkylators for anticancer activity against several panels of human cancer cell lines (breast cancer, colon cancer, pancreatic cancer, small-cell-lung cancer cells) showed that these compounds produce their cytostatic and cytotoxic effects independently of the presence of different inactivating mutations of TP53 (data not shown).