The B-lactam- steroid alkylators ASA-A, ASA-B and ASA-C, as well as the alkylating moiety POPA and the PARP inhibitors 3-AB and Olaparib were tested for their genotoxic effects on PHA-stimulated T-lymphocytes obtained from five healthy donors, as well as on UWB1.289 and UWB1.289 +BRCA1 human ovarian cancer cells at a concentration of 3 μM. This evidence concerns the gene PARP1 and ovarian carcinoma.