PARP1 and cancer: The tested hybrid homo-aza- (lactam) steroidal alkylating esters exert their cytostatic and cytotoxic effects on cancer cells combining multiple pharmacological functions, including the induction of genotoxic effects and DNA damage through their alkylating moiety, as well as the inhibition of PARP activity by binding on its catalytic site [17,18,19,20,21].