PARP inhibitors are approved as a frontline maintenance treatment for patients with and without BRCA-associated cancers, and clinical data demonstrate the effectiveness of PARP inhibition in women with recurrent epithelial ovarian cancer harboring BRCA1/2 mutations and those with platinum-sensitive disease as a maintenance therapy or as a second-line treatment in recurrence [37,38]. The gene discussed is PARP1; the disease is ovarian carcinoma.