On the other hand, the B-lactam steroidal alkylator ASA-A induced the strongest cytostatic and cytotoxic antitumor results in all tested ovarian cancer cell lines, and while it proved a potent PARP inhibitor in a cell free assay, the synthetic lethality in BRCA-1 “null” UWB1.289 cells could not be as evident. This evidence concerns the gene BRCA1 and ovarian carcinoma.