PIK3CA and ovarian carcinoma: Moreover, SKOV-3 ovarian cancer cells that bear an active mutation on the PIK3CA gene and present a high microsatellite instability (MSI-high), in contrast to the OVCAR-3 and UWB1.289 + BRCA1 ovarian cancer cells that are microsatellite-stable (MSS), demonstrate a clearly higher susceptibility to the anticancer activity of ASA-A and ASA-B as far as their cytostatic effects and the 100% cell growth inhibition (TGI) are concerned (t-test, p < 0.01).