Most other ALS cases are familial, with a Mendelian pattern of inheritance resulting from a number of gene mutations, including mutations in the genes for superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP-43), fused in sarcoma (FUS) and C9orf72 [4]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.