STAT3 and colorectal carcinoma: Although there are findings that attribute STAT3 either an oncogenic or a tumor-suppressive role in solid tumors and CRC, it has been widely accepted that STAT3 activity mainly lies on STAT3 homodimerization and activation for gene transcription, which regulates proliferation, apoptosis, invasion and metastasis, angiogenesis, and TM immune status in CRC.