TGFB1 and Hepatic fibrosis: TGFβ-1-induced transcript 1 protein (TGFβ1i1), also named as hydrogen peroxide-inducible clone-5 (Hic-5), inhibits the activation of HSCs and liver fibrosis through reducing the TGF-β/Smad2 signaling by upregulation of Smad7 [71].