The majority of the HTRA2-specific interaction partners were involved in ER to Golgi anterograde transport, protein localization to membrane, aggrephagy, pyruvate metabolism and citric acid (TCA) cycle, signaling by FGFR2 IIIa TM, HIV infection, and SIG regulation of the actin cytoskeleton by RHO GTPases. Here, HTRA2 is linked to HIV infectious disease.