(4) Treadmill training repaired the impairment of mitophagy in Parkinson’s disease, supported by the evidence that treadmill training reduced the levels of dysfunctional mitochondria detectors (PINK1, parkin, and p62) and increased the levels of lysosomal factors (LAMP2 and cathepsin L) in the Parkinsonian brain. The gene discussed is PINK1; the disease is Parkinson disease.