In the included studies, treadmill training reduced mitophagy detectors (PINK1, parkin, and p62) but there was no change in autophagosomal factors (beclin-1 and LC3II) in Parkinson’s disease [15,20,27], suggesting that treadmill training reduced the accumulation of dysfunctional mitochondria as well as maintained autophagosome flux in Parkinson’s disease. The gene discussed is PINK1; the disease is Parkinson disease.