FL-OPN and Ud-OPN indicated a high area-under-the-curve (AUC) value between normal versus TB (AUC: around 0.99) and normal versus AIDS/TB (AUC: around 0.97), suggesting that FL-OPN and Ud-OPN can discriminate normal and TB as well as normal and AIDS/TB. The gene discussed is SPP1; the disease is tuberculosis.