To this end, we pre-defined a specific gene panel, consisting of genes which have been previously associated with PCa: AR-FL (androgen receptor-full length), AR-V7 (variant 7), PSMA (prostate-specific membrane antigen), KLK-2 (kallikrein-2), PSA (prostate specific antigen), AKR1C3 (aldo-keto reductase 1 C3), ERG (ETS-related gene), TMPRSS2 (transmembrane protease, serine 2), FASN (fatty acid synthase), and TP53 (tumor protein 53). Here, TMPRSS2 is linked to posterior cortical atrophy.