The few existing studies in endothelial cells show an effect of ANGPTL3 on cell adhesion and angiogenesis [58], providing support to the hypothesis that, in addition to the effect on lipids, ANGPTL3 has a direct impact on endothelial cells, and likely on atherosclerosis, of which neo-angiogenesis is an important hallmark [61]. Here, ANGPTL3 is linked to atherosclerosis.