NLRP3 and COVID-19: In COVID-19, pyroptosis may be activated by the hyperinflammatory status, inducing the NLRP3 (nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3) inflammasome, which, in turn, leads to caspase-dependent release of the pro-inflammatory cytokines (IL-1β, IL-6, and IL-18) and gasdermin D, the effector protein of pyroptosis [90].