WNK2 and chronic myelogenous leukemia, BCR-ABL1 positive: COS induced the apoptosis in other cancer cells, including DOX-resistant chronic myeloid leukemia (K562/ADR) cells through inhibition of the phosphoinositide 3-kinase/protein kinase B pathway [31] and prostate cancer cells via activated mitogen-activated protein kinases and generation of ROS [32].