BCL2 and ovarian carcinoma: Similarly, Yang et al. [34] stated that COS induced the apoptosis of platinum-resistant ovarian cancer cell lines (MPSC1(PT), A2780(PT), and SKOV3(PT)) in a time- and dose-dependent manner and suppressed tumor growth in a SKOV3(PT)-bearing mouse model through activation of caspase-3, -8, and, -9 and downregulation of Bcl-2.