INS and lipodystrophy: However, there is also an important category of serious side effects reported to varying degrees: lactic acidosis, impaired liver function and/or lipodystrophy (redistribution of adipose tissue), for NRTI; urticaria, Steven-Johnson syndrome, toxic epidermal necrolysis after NRTI administration; hepatotoxicity, dyslipidemia, hyperglycemia and resistance to insulin, hypercholesterolemia, hypertriglyceridemia, lipodystrophy, for PI [13].