BAK1 and neoplasm: Resistance against apoptosis, a typical hallmark of cancer, is based on an upregulation of anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-xl, Mcl-1) in PC cells [100] Interestingly, the pro-apoptotic members Bax and Bak are omnipresent in all tumor stages and mutations in these proteins that could affect their function are very rare [100,101].