This anti-CD70 ADC showed a significant cytotoxicity on SK-LMS-1 cells, displaying IC50 equal to 0.120 nM and it strongly inhibited tumor growth in SK-LMS-1 xenograft mouse models and in uterine leiomyosarcoma PDX mouse models with a relative tumor reduction of 54.5% and 84.7%, respectively [79]. This evidence concerns the gene CD70 and leiomyosarcoma.