Immunochemical data showed an increase in active caspase-3 (Figure 4A,B), PCNA expression (Figure 4C,D), and downstream signaling of phosphorylated AKT (Figure 5A,B) in kras+/LPS zebrafish compared with kras+ zebrafish, which suggests that LPS is associated with intestinal tumor formation. This evidence concerns the gene CASP3 and intestinal neoplasm.