STAT3 and breast carcinoma: Proietti and collaborators [42] showed that in murine (C4HD) and human (T-47D) breast cancer cells, treatment with the synthetic progestin medroxyprogesterone acetate (MPA) promoted phosphorylation of Y705 STAT3 and consequent nuclear translocation, SIE binding, and STAT3-dependent transcriptional activation mediated by JAK- and Src-dependent pathways.