EZH2 and glioblastoma: The STAT3-EZH2 interaction seems to be fundamental in glioblastoma multiforme stem-like cells (GSCs), being responsible for glioblastoma multiforme (GBM) spread, therapy resistance, and relapse [83]; Kim and collaborators, using GSCs, demonstrated that EZH2 induced transcriptional silencing, and also activated STAT3.