In 2000, Decker and Kovarik [34] noticed some contrasting results reviewing information available about the function of S727 phosphorylation, while Schuringa et al. [35] confirmed in hepatoma cells stimulated with IL-6s the results of Wen et al., and Kim and Baumann [36] reported that STAT3 wild type and STAT3 S727A activities on hepatoglobin acute phase promoter were similar. The gene discussed is STAT3; the disease is hepatocellular carcinoma.