The translocation (8;21) results in the creation of a chimeric gene RUNX1/RUNX1T1, while inv(16), or with significantly lower incidence t(16;16), leads to the fusion of the CBFB gene with MYH11, the smooth muscle myosin heavy chain gene, resulting in the chimeric CBFB-MYH11 gene, which occurs in approximately 8% of adults with de novo AML [4]. The gene discussed is CBFB; the disease is acute myeloid leukemia.