While internal tandem duplication (ITD) is the most frequent in cytogenetically normal AML, holding an unfavorable prognostic impact depending on allelic burden, FLT3 tyrosine kinase domain (TKD) point mutations represent the most common alteration, in inv(16) AML, being associated with BM blast percentage [16]. This evidence concerns the gene FLT3 and acute myeloid leukemia.