The recent observation of CBFB-MYH11-specific T cells indicates that CBFB-MYH11 fusion neoantigen is naturally processed and presented on AML blasts and enables T cell recognition and the killing of leukemic cells, supporting the hypothesis of a potential contribution of specific cytotoxic cells in MRD control and CCR maintenance [96]. Here, CBFB is linked to acute myeloid leukemia.