When the kinetics of transcript levels rising was evaluated, a slower rate of MRD increasing for CBFB-MYH11 AML was observed, as compared to NPM1 or PML-RARA positive AML, with a BM doubling time of 36 days and the longest lag before morphological relapse (even 8 months) [98], suggesting the need for longer monitoring. This evidence concerns the gene NPM1 and acute myeloid leukemia.