This is substantiated by a study that revealed an overall protective ability of HDL, specifically APOA1, to induce tumor suppression through both innate and adaptive immune processes in multiple animal tumor models [29,30], which demonstrated that HDL’s anti-inflammatory properties were conferred, in part, through HDL-micro-RNA (miR)-223 delivery and the translational repression of ICAM-1 in endothelial cells. The gene discussed is ICAM1; the disease is neoplasm.