FN1 and open-angle glaucoma: The mechanism responsible for the IOP elevation has been proposed to involve an increase in the resistance to the outflow of aqueous media from the trabecular meshwork (TM), presumably caused by the deposition of higher than normal levels of extracellular matrix (ECM) molecules such as collagen molecules (COLs), fibronectin (FN), and others leading to the development of both primary open-angle glaucoma (POAG) and steroid-induced glaucoma (SG) [4,5].