The gold standard for non-small cell lung cancer (NSCLC) genotyping is the analysis of different driver genes such as EGFR, BRAF, HER2, KRAS, and MET, as well as rearrangements in ALK, ROS1, RET, and NTRK1/2/3 [23,24], typically analyzed by PCR-based assays, immunohistochemistry (IHC), and fluorescent in situ hybridization assays (FISH) [25]. This evidence concerns the gene ROS1 and non-small cell lung carcinoma.