Therefore, in the current study, we aimed to investigate the expression of SGLT2, SIRT6, leptin, and inflammatory markers expression in the pericoronary fat and the clinical prognosis at one year of follow-up comparing PDM to normoglycemic (NG) patients subjected to coronary artery bypass grafting (CABG) for acute myocardial infarction (AMI). The gene discussed is SIRT6; the disease is myocardial infarction.