In human primary osteoblasts, ObR antisense oligonucleotides abolished the leptin-mediated production of oncostatin M [56], which, as a member of the IL6 family, has been associated with bone remodelling and cartilage volume loss in OA and RA [102] as well as ObR itself being associated with biomarkers of cartilage loss and bone remodelling over 2 years in knee OA patients [103]. Here, LEP is linked to rheumatoid arthritis.