Characteristic laboratory abnormalities in APS include persistently elevated levels of antibodies directed against membrane anionic phospholipids (e.g., anticardiolipin antibody (aCL)) or their associated plasma proteins, predominantly beta-2 glycoprotein I (β2GPI), or evidence of a circulating lupus anticoagulant (LA). The gene discussed is ACLY; the disease is autoimmune polyendocrinopathy.