EGFR and colorectal cancer: With regards to targeted therapies used in the treatment of colorectal cancer and their metastases, the main forms of this type of therapy are Tyrosine Kinase Inhibitors, BRAF (proto-oncogene B-Raf or v-Raf murine sarcoma viral oncogene homolog B) inhibitors and epidermal growth factor receptor (EGFR) inhibitors (Figure 2).