ORA of protein partners in KEGG, REACTOME, Panther and WikiPathways databases showed their involvement in nucleotides biosynthesis and metabolism, amino acids pathways, synaptic signal transmission, protein processing in endoplasmic reticulum (ER), ER quality control (ERQC) and cancer-related pathways (apoptotic pathway, MAPK family signaling cascades, metabolic reprogramming and central carbon metabolism in cancer, Ras signaling, RAC1/PAK1/p38/MMP2 pathway and three cancer-specific pathways in prostate, endometrial and bladder cancers) (Table S2, Supplementary File #1). The gene discussed is PAK1; the disease is urinary bladder cancer.