The diagrams in Figure 5B,C and the data in Table S3 demonstrated that protein kinases (AMPK, PRKACA, MEK5/ERK5, GSK3B, PKC and ILK), protein phosphatases (PP2A, PPP1CB, DUSP6 and PTPN5) and proteases (CTSL, CASP7 and CAPN1) are highly enriched in terms of cancer hallmark and cancer pathways terms. This evidence concerns the gene MAP2K5 and cancer.