Annotation of genes, encoding 165 unique protein partners of enzymes, showed that following ones were found as cancer drivers with corresponding somatic mutation frequency values: PRKACA (0.7%); EWSR1 (1.2%); NDRG1 (0.8%); FGFR1 (1.4%); IDH1 (5.1%); PABPC1 (0.9%); LMNA (0.8%); MYH9 (3.2%); SUZ12 (1.0%); TP53 (35.3%); HRAS (1.2%); IKBKB (1.4%); CYLD (1.3%); ERBB2 (2.9%). The gene discussed is CYLD; the disease is cancer.