Genetic mutations in adrenocortical malignancies have been detected in tumor suppressor genes such as TP53 and RB1 [17,71,72], mutations in Wnt-β-catenin system genes such as ZNRF3 and CTNNB1 [17,21,71], mutations in cell cycle-related genes such as CDKN2A [17], and mutations in epigenomic and chromatin remodeling regulators such as DAXX, MED12, and MEN1 [17,71]. This evidence concerns the gene RB1 and neoplasm.