In addition, IGF2 (insulin-like growth factor 2), PRKAR1A, RPL22 (ribosomal protein L22), CCNE1 (cyclin E1), CDK4 (cyclin dependent kinase 4), TERT (telomerase reverse transcriptase), and TERF2 (telomeric repeat binding factor 2) have also been reported as genetic mutations in ACC [20]. This evidence concerns the gene CCNE1 and adrenal cortex carcinoma.