In HCC patients miR-21, but not miR-122, was positively correlated with HIF-1α both at t0 (r = 0.34 [95% CI 0.00–0.61]; p = 0.045) and at t1 (r = 0.35 [95% CI 0.02–0.61]; p = 0.035) (Figure 5). This evidence concerns the gene HIF1A and hepatocellular carcinoma.