Intriguingly, one recent large-scale study [4] showed that many cancers have an inflammatory gene network that involves interactions of the transcription factors STAT3, NF-κB, and AP-1 at common DNA sites where NF-κB, in many cases, is only indirectly associated with DNA by virtue of its interaction with STAT3 or AP-1 on DNA. Here, NFKB1 is linked to cancer.