GSK3B and acute kidney injury: In cisplatin-induced AKI, although we first demonstrated the activation of GSK-3β caused by cisplatin in vivo in kidneys and in vitro in proximal tubular epithelial cells, the potential regulation underlying cisplatin-induced GSK-3β activation in renal tubular cells and their effects on GSK-3β-modulated pro-apoptotic factors [14,31] as well as pro-inflammatory factors [17,18] requires further investigation.