Treatment of U251 glioma cells with BFP induced generation of the reactive oxygen species (ROS) and also increased expression of the endoplasmic reticulum (ER) stress markers such glucose-regulated protein (GRP)-78, GRP-94, IRE1, phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF-2) and induced upregulation of the CAAT/enhancer-binding protein homologous protein (CHOP). This evidence concerns the gene DDIT3 and central nervous system cancer.