PFKFB3 and glioma: The results of the study devoted to the influence of this sulfated saponin on the expression levels of glioma metabolic enzymes of glycolysis and glutaminolysis demonstrated that this compound (4 μM) significantly lowers the expression levels of HK2, PFKFB3, PKM2, and GLS in U87-MG cells after 24 h treatment [113].