Moreover, human post-mortem AD brains show a downregulation of genes related to mitochondrial influx Ca2+ transporter, MCU, and its regulatory subunits, and an upregulation of genes involved in mitochondrial Ca2+ efflux pathways, SLC8B1 (encoding NCLX), suggesting an adaptive mechanism to prevent mitochondrial Ca2+ overload [31]. This evidence concerns the gene MCU and Alzheimer disease.