Totally, top five obesity-related KEGG pathways were metabolic pathways (hsa01100), pathways in cancer (hsa05200), PI3K-Akt signaling pathway (hsa04151), neuroactive ligand-receptor interaction (hsa04080), and MAPK signaling pathway (hsa04010) in order of precedence (Table 4), while top five obesity-related GAD disease classes were metabolic, cardiovascular, chemdependency, immune, and neurological in order of precedence (Table 5). This evidence concerns the gene AKT1 and obesity due to melanocortin 4 receptor deficiency.