Insulin-dependent co-localization of RAB3C and insulin-sensitive glucose transporter GLUT4 (Solute carrier family 2 member 4 (SLC2A4) named in human) in cardiac muscle of lean Zucker rats disappeared in obese Zucker rats [29], indicating a possible involvement of RAB3C in the pathogenesis of insulin resistance in obese animals. This evidence concerns the gene SLC4A2 and Insulin resistance.