PRDX5 and cancer: As suggested by the literature, the inhibition of the thioredoxin reductase–thioredoxin redox system by gold(I) and gold(III) complexes (e.g., auranofin and AuL12) and the subsequent production of ROS are able to trigger cancer cell apoptosis through mitochondrial impairment [16,32,33,34,35,36].