The microenvironment of transformed tissue consists of different cell populations, including tumor cells, fibroblasts, endothelial cells, cancer-associated stromal cells, neutrophils, macrophages, which secrete immune response mediators, and effectors in proliferation, cell cycle, apoptosis, and invasion [84,85,86] Certainly, NF-κB transcription factors are widely involved in these processes (Table 2). This evidence concerns the gene NFKB1 and cancer.