A ubiquitously expressed CXC chemokine CXCL12, which usually stimulates the migration of monocytes and T-lymphocytes, induces NF-κB pathway-dependent expression of its receptor CXC chemokine receptor 4 (CXCR4) and epidermal growth factor receptor (EGFR) in GC cell lines, which further activate IKKα/ß and RelA and increase cell migration ability [147]. Here, NFKB1 is linked to gastric cancer.