Accumulating findings have recently demonstrated that EMT may induce chemotherapy resistance and cancer cell stemness by regulating EMT transcription factors, such as Zeb1, Zeb2, Snail, Slug, and Twist1, in a complicated network, and all functional EMT in the tumor microenvironment could exchange tumor cell morphology to upgrade metastatic abilities via migration and invasion [72,111,112,113]. Here, TWIST1 is linked to neoplasm.