CD40 and macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss: In mice, experimental autoimmune encephalomyelitis is associated with sickness behavior syndrome (SBS), characterized by weight loss, sleep disruption and depression and has been correlated with pro-inflammatory cytokines [19], while inhibition of CD40 or CD40L rendered mice resistant to experimental autoimmune disorders [2,6].