Previously, PPARγ agonists such as ciglitazone, mifepristone, 15d-PGJ2/15-PGJ(2), and pioglitazone were found to effectively alleviate cerebral ischemia-reperfusion injury in rats after MCAO, i.e., middle carotid artery occlusion [20,21,22] and bilateral common carotid artery occlusion [23]. The gene discussed is PPARG; the disease is brain ischemia.