Several studies show that high infiltrations of CD3+ and/or CD8+ T lymphocytes within CRC tumors and their invasive margins were associated with early stages of the disease (TNM stages I-II) and other good prognostic indicators, including absence of lymph node metastasis and distant metastasis [19,38]. The gene discussed is CD8A; the disease is metastatic malignant neoplasm in the lymph nodes.