Mitochondrial dysfunction and oxidative stress are also associated with fibromyalgia, and a study by Cordero and Miguel demonstrated that, after taking 300 mg of CoQ10 per day for 40 days, patients exhibited enhanced activities of antioxidant enzymes, decreased expression of inflammatory cytokines and increased expression of PGC-1α and TFAM [52]. Here, PPARGC1A is linked to fibromyalgia.