Another noteworthy factor is that SHH-GLI signalling has been associated to proliferation, survival, self-renewal and tumorigenicity of cancer stem cells with several markers of stemness differently characterizing the grade, growth and survival of pathology, [49,50,51], so that pharmacological modulation of SHH pathway has been proposed in different therapeutic plans to prevent tumor proliferation and recurrence [52]. This evidence concerns the gene SHH and neoplasm.