In particular, CX43 proved to be an attractive target for GBM since it is dynamically expressed by highly invasive glioblastoma cells, showing a multifaceted appearance dependent on both GBM growth level and malignant phase so that some tumor cells would be expected to migrate (CX43 expressing cells) and others to proliferate (CX43 non-expressing cells) [31]. Here, GJA1 is linked to neoplasm.