GJA1 and neoplasm: It has been proposed that CX43 regulates the expression levels of proteins involved in cell growth independently by their channel forming properties, given the multifaceted role of CX43 carboxyl tail, which exerts a number of effects ranging from controlling the translocation of transcription factor regulators into the nucleus to the enhancing of the migration of glioma cells out of the tumor core by interacting with cytoskeleton elements [31].