The invasive behaviour of glioma cells induced by CX43-dependent signalling has been previously described by studies reporting that CX43 increases the secretion and activation of proteins associated with cell motility and extracellular matrix remodelling, also due to the tumorigenicity activation of neural progenitor spheroids and glioblastoma stem cells [46,47,48]. Here, GJA1 is linked to central nervous system cancer.