Later, the aqueous humor proteome of POAG and PACG, compared to patients with cataracts, was also explored via LC–MS/MS, obtaining 28 proteins as constitutive of the fluid proteome, of which the monocyte differentiation antigens CD14, CD59, complement factor D (CFD), APOA4, chromogranin A (CHGA), and MYB involved in immune response, the TIMP1 involved in the coagulation system, and the microfibril-associated glycoprotein 4 (MFAP4), agrin (AGRN), and apolipoprotein C-III (APOC3) involved in the response to light stimulus, were found to be upregulated [91]. This evidence concerns the gene MFAP4 and open-angle glaucoma.