GAPDH and open-angle glaucoma: Joachim et al. found significant differences in the antibody profiles of glaucoma patients, observing upregulation of heat shock protein (HSP)70 and vimentin (VIM) in NTG subjects [83], in addition to HSP27 overexpression and α-enolase (ENO1), actin, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) downregulation in both POAG and PEXG patients, when compared to controls [84].