The candidates caldesmon (CALD1), phosphoglycerate mutase 1 (PGAM1), and voltage-dependent anion-selective channel protein 2 (VDAC2) were significantly higher in POAG patients when compared to control subjects, establishing a panel with the additional heat-shock protein 60 Kda (HSPD1) and VIM, reaching 81% sensitivity and 93% specificity in the diagnosis of glaucoma. This evidence concerns the gene CALD1 and open-angle glaucoma.