Furthermore, the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) was found to be increased in POAG patients when compared with cataractous control patients, stating that despite some conflicting results, oxidative stress during glaucoma leads to an induction of antioxidant enzymes, these being candidate stress markers in the aqueous humor of glaucoma patients [63]. Here, SOD1 is linked to open-angle glaucoma.