Up: APOA4 (2.7-fold POAG vs. CT, 1.5-fold PEXG vs. CT, 1.8-fold POAG vs. CT), C3 (1.5-fold POAG vs. CT, 1.4 fold POAG vs. PEXG), TTR (1.8-fold POAG vs. CT, 1.5-fold POAG vs. PEXG), TF (1.7-fold POAG vs. CT, 1.5-fold POAG vs. PEXG), VTN (2.2-fold POAG vs. CT, 1.6-fold PEXG vs. CT), fibulin-1 (FBLN1, 1.9-fold POAG vs. CT, 1.5-fold PEXG vs. CT), APOA1, 1.3-fold POAG vs. CT), alpha-1 antitrypsin (SERPINA1, 1.5-fold POG vs. CT, 1.3-fold POAG vs. PEXG), CFH (1.3-fold POAG vs. CT), apolipoprotein L1 (APOL1, 1–4-fold POAG vs. CT), ficolin-3 (FCN3, 1.3-fold POAG vs. CT, 1.3-fold POAG vs. PEXG). This evidence concerns the gene APOA4 and open-angle glaucoma.