TNF and open-angle glaucoma: Continuing with the suggested proinflammatory environment observed during glaucoma, the analyzed vitreous levels of the cytokines IL-2, IL-5, MCP-1, TNF-α, and IFN-γ-induced protein-10 (IP-10) were significantly higher in AACG, while IP-10 was also upregulated in both POAG and CAGG, when compared to controls, confirming the local inflammation and immune reaction during glaucoma [111].