VSIG4 and glaucoma: These significant differentially expressed proteins were involved in the cholesterol upregulation of angiotensinogen (AGT), apolipoprotein C-I (APOC1), and APOA4, inflammatory complement component C1q (C1q), complement component C8 beta chain (CO8B), complement C9 (CO9), and V-set and immunoglobulin domain-containing protein 4 (VSIG4), as well as metabolic-, antioxidant-, and proteolysis-related processes, indicating altered metabolic state, inflammatory response, and impaired antioxidant defense during glaucoma.