Thereby, the levels of CTGF—a matricellular protein that may play a role in the deposition of elastic microfibrillar exfoliation material, and interacts with the cytokine TGF-β—determined by ELISA were significantly higher in the aqueous humor of patients with PEXG than that of both POAG and control subjects [75]. This evidence concerns the gene CCN2 and open-angle glaucoma.