Likewise, the quantitative analysis by LC–MS/MS of human retinal protein samples from glaucoma (n = 10) and control (n = 10) donors, showed many upregulated retinal proteins in glaucoma involved in TNF-α/ tumor necrosis factor receptor 1 (TNFR1) signaling, which is implicated in death receptor-mediated caspase cascade, mitochondrial dysfunction, endoplasmic reticulum stress, calpains leading to apoptotic cell death, the nuclear factor-κB (NF-κB) and JAK/STAT pathways, and inflammasome-assembly-mediating inflammation [122]. The gene discussed is TNF; the disease is glaucoma.