Interestingly, a proteomic analysis based on 2D electrophoresis and LC–MS/MS, and carried out in five POAG patients with uncontrolled IOP—despite the use of well-tolerated medical therapy—and five control subjects showed significant upregulation of TTR, as well as prostaglandin H2 D-isomerase (PTGDS, validated by WB), caspase 14 precursor, CysC, albumin (ALB) precursor, and transferrin (TF), which could play roles in the apoptosis of the trabecular meshwork [87]. This evidence concerns the gene PTGDS and open-angle glaucoma.