The main results showed that POAG patients had lower levels of several tear amino acids and lysophospholipids compared with controls—i.e., alanine, arginine, glycine\lysine, leucine\isoleucine\proline-OH, methionine, phenylalanine, proline, valine, C2, C22:0-lisofosfatidilcolina(LPC), and C24:0-LPC—lower concentrations of thioredoxin (TXN), actin, and ACTG1, and higher levels of the proteins LYZ, junction plakoglobin (JUP), and protein PML. Here, JUP is linked to open-angle glaucoma.