NGB and open-angle glaucoma: On the other hand, neuroglobin—a hypoxic sensor and initiator of signal transduction involving oxidative and hypoxic pathways—was determined in POAG patients, showing high upregulation (5.2-fold) when compared with control subjects, with an AUC of 0.82, suggesting neuroglobin as an interesting candidate biomarker for the diagnosis of glaucoma [194].