TNF and glaucoma: For example, histopathological studies revealed an increased immunostaining for TNF-α and TNF-α receptor in the glaucomatous optic nerve head and retina sections compared to age-matched control eyes, suggesting that TNF-α-mediated cell death is involved in the neurodegeneration process of glaucoma, in agreement with studies performed in the aqueous humor and vitreous body [116,117,118].