A liquid chromatography tandem mass spectrometry (LC–MS/MS) proteomics analysis carried out in the aqueous humor of POAG (n = 90), PACG (n = 72), and control (n = 78) subjects showed the under-regulation of the extracellular matrix proteins OPN, CD, and cystatin C (CysC), which was further validated by Western blot (WB), with the exception of CD [78]. Here, SPP1 is linked to open-angle glaucoma.