However, in a recent prospective study, the serum levels of SOD and total antioxidant status (TAS) determined spectrophotometrically in PACG patients were significantly lower than those in the control group, while MDA and hydrogen peroxide were higher in individuals with glaucoma, with 5.5- and 2.2-fold change, respectively, suggesting that oxidative stress may be involved in the onset and development of PACG [160]. This evidence concerns the gene SOD1 and glaucoma.