This is in agreement with previous small studies [57,58,59,60,61,62] and was recently confirmed by a large observational nationwide study in England [63] where metformin, SGLT2 inhibitors, and sulfonylureas resulted in an association of reduced risks of the COVID-19-related mortality, whereas insulin and DPP-4 inhibitors were associated with an increased risk, and neutral results were found for GLP-1 receptor agonists and thiazolidinediones. This evidence concerns the gene INS and COVID-19.