It was known that AR amplification sensitizes prostate cancers to low levels of androgen, that PI3K (PIK3CA/B) and Wnt (RSPO2) pathways can bypass the AR function for cell proliferation, and that CCND1 regulates the cell cycle; therefore, all five genes are involved in mCRPC [25]. The gene discussed is RSPO2; the disease is prostate carcinoma.