Unfortunately, hyperactivated neutrophils and monocytes-macrophages are the usual source of the cytokine storm, and a recent study conducted on about 500 COVID-19 infected patients highlighted that the cytokine storm was mediated by high-levels of proinflammatory cytokines and identified that severe cases showed significantly higher cytokines and chemokines such as TNF-α, IL-6, and IL-10 expressed [39]. The gene discussed is TNF; the disease is COVID-19.