CD4 and infection: However, both the CD4+ T and CD8+ T counts may serve as biomarkers for predicting the severity and recovery from COVID-19 [65], and our results underlined a negative correlation with the outcome of the CD8+ T lymphocyte count at the first observation, but on the other hand, they also highlighted a positive correlation between a rise in CD4+ and CD8+ during infection and in the CD4+/CD8+ T lymphocyte ratio and a favorable outcome.