As HIF-1α can directly influence the expression of two PD-related genes, LRRK2 and ATP13A2, through the HREs present in their promoters, and hypoxia can trigger α-synuclein accumulation, it would be of interest to explore the impact of hypoxia and HIF-1α in the expression of other PD-related genes to elucidate possible common mechanisms. Here, HIF1A is linked to Parkinson disease.