PRKN and Parkinson disease: Whilst still an area of active research, the PINK1/Parkin pathway appears to participate in this process by regulating the phosphorylation and ubiquitination of PARIS, a known repressor of PGC-1α and Nrf1, in murine SN DAergic neurons and DAergic neurons derived from both hESCs and PD patients’ iPSCs [113,114].