A1-mediated altered translation has been implicated in cellular proliferation and cancer, where growth factor receptors and oncogenes like FGF-2 (fibroblast growth factor 2), MYC (c-Myc), IQGAP1 (IQ motif containing GTPase activating protein 1), and CYLD (cyclin D1) are aberrantly translated [119,166,173,174,175]. Here, IQGAP1 is linked to cancer.