However, a series of recent work has tied A1, A2/B1, miR-Let-7a, miR-206, the oncogenic long non-coding RNA LINC01234, CRY2 (cryptochrome 2), PKM2 (pyruvate kinase M2, an oncogenic splice variant of PKM1), and c-Myc in a complicated web of reciprocal modulation that, when dysregulated, induces an oncogenic transcriptional and splicing profile in a number of cancers [151,157,158,159,160]. The gene discussed is MYC; the disease is cancer.