hnRNP A/B family proteins have long been recognized as autoantibody targets in a subset of autoimmune diseases like rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), mixed connective tissue disease, scleroderma, Sjorgren’s syndrome, and MS [41,204,205,206,207,208,209,210,211,212]. This evidence concerns the gene HNRNPAB and systemic lupus erythematosus.