The sleep-wake cycle has been examined across different pathological stages in various mouse models, including 3xTg-AD [233,234], APP/PS1 [234,235], Tg2576 [234,236], P301S Tau [237], rTG4510 [238], PLB1Triple [239], and PLB2tau [240] models (Table 3). Here, MAPT is linked to Alzheimer disease.